Aristolochia baetica (A. baetica) is a wild species ofAristolochiaceae family; its roots are used byMoroccan people against cancer for\nmany years ago. The objective of the study was to investigate the phytochemical screening, acute and subacute toxicity of A. baetica\nroots growing in the north of Morocco. Qualitative and quantitative analyses of A. baetica roots were performed using standard\nmethods; the acute toxicity of the root extract of the studied plant was assessed in mice by gavage of single doses of 1, 2, and 4 g/kg\nbody weight for 14 days; by the time the subacute toxicity was done using repeated doses 1, 1.5, and 2 g/kg/day for 28 days.Histological\nchanges and biochemical parameters asmarkers of kidney and liver functionwere evaluated.Theresults of phytochemical screening\nshowed the presence of polyphenols, tannins, alkaloids, flavonoids, saponins, and the absence of anthraquinones, sterols, and\nterpenes.The results of acute toxicity showed the absence of mortality and signs of toxicity in groups treated with 1 and 2 g/kg;\nhowever, the clinical signs of toxicitywere important and the rate of mortality was estimated at 16%in the group treated with 4 g/kg.\nThe results of subacute toxicity showed several changes of serum parameters registered in groups treated with 1.5 and 2 g/kg/day,\nrespectively.The results showed also the absence of histological injuries in groups treated with 1 and 1.5 g/kg/day; meanwhile, the\nhistological alterations were remarkable in treated group with the highest dose administered of 2 g/kg/day. The outcome of this\nwork showed that the rootsâ?? extract of the studied plant was toxic inmice with repeated doses, but no toxic effect was observed with\na single dose under 4g/kg.
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